中晚期肺癌患者外周血CIK細(xì)胞水平及臨床意義研究.pdf

1、學(xué)校代碼：10132學(xué)員編號：2003022中圖分類號：R7342R73051喲攀爸逢亨饒l躐黼簸耩嬲國黼臻雅＆l凝瓣鞋黲l霰蕊乳鬈酶歉鬏甄翁囂簇。：學(xué)能逾文中晚期肺癌患者外周血CIK細(xì)胞水平及臨床意義研究學(xué)科專業(yè)：研究生：指導(dǎo)教師：完成時間：內(nèi)科學(xué)喬曉娟李云霞教授二oo六年五月ABSTRACT0bjec廿veT0explorethechangesonthelevelofCII(ceUsinPeripheralbloodinpa—tie

2、mswidladvancedlungcanceraIldt0an8lyseit8clinicalsi伊遺canceM劬od57patient8withTNM8tageⅢaIldⅣlungcancerwerestudiedCIKcellsaIldTlymphocyte8llbsetinpelripheralb100dweIledetectedbynowc”omenySerumCAI叢concen仕ationw幽me髂uredbyeIlzy

3、me—linkediITIInunosorbent酗say(EUSA)35patientsTeceived3cycles0fchemotllera—pyCIKeeⅡsleveIinpe工ipheralbloodintllosepadentswasa180me鵲礬dtwoweeks“Ie。chemothempy27healdlyvolunteerswerechosenascontr01脅lllt(1)111elevel0fCIKceusi

4、np謝pheralb100dinpatientswi山lungcaIIcer(680134)％wassi印墑c鋤dyhigherth粕thatinn0珊als幽ects(338O79)％(pO05)，(3)nekvelofCⅨceUsinperipheralb100draisedwimtleincre鵲ingofTNMstagesⅢ。stage(589O67)％，Ⅲ8Ⅳstage(762l25)％(PO05)(4)35Post—chem

5、otherapycasesshowedlowerCIKcellskvel(278116)％chanpre—chemo山er印ycases(699I53)％(P005)(5)cIKceUsinpenpheraIbloodwascon℃latedn。gatively“thCD3、cD4‘a(chǎn)ndcD8ceUs，andhadm8rkedcorrelation試thserumCAl25concentradonConcl惦ionTherewasan

6、elevatedCIKceUslevelinpati朗tswithadvancedlungcancerIthadsigni6cantlyanti—tumore玨bctItshowednelationtopatholo百caltypesButinwasa雎ctedbyTNMstageandt1erapy，andhadcorrelationtoTlymPhocytesllbsetandCAl25Itmaysened踮aIlus幽Iindic