胰島素樣生長因子-1及其受體在子宮內(nèi)膜癌中的表達及意義.pdf

1、青島大學碩士學位論文胰島素樣生長因子1及其受體在子宮內(nèi)膜癌中的表達及意義姓名：遲小巖申請學位級別：碩士專業(yè)：婦產(chǎn)科學指導(dǎo)教師：王言奎20080518AbstractObjectiveTostudytheexpressionofinsulinlikegrowthfactorl(IGF1)，insulin—likegrowthfactor1receptor(IGFlR)inendometrialadenocarcinomaandthecli

2、nicalsignificanceMethodsThetissuespecimensof46patientswithendometrialadenocarcinomawereformalin—fixed，paraffinembeddedcutandmountedontotheslidesSectionswerestainedforIGF—l，IGF—IRimmunohistochemicallyTwentyspecimensofnorm

3、alendometriumservedascontr01Results(1)percentsspecimensofthecontrolgroupwerepositivestainingofIGF一1，withoutoverexpressionPositiveexpressionofIGF一1Wasin6087％ofthecancerwithoverexpressionin2391％(moderatestainingin17casesan

4、dstrongstainingin11cases)Nosignificantdifferenceofpositiveexpressionratewasobservedbetweeneanograndnormalgroups(’間004，P=o947)，butsignificantdifferenceofoverexpressionratesWasobtainedbetweennormalandcancergroupsC=4147，P=0

5、003)PositiveexpressionandoverexpressionofIGF1werenotassociatedwithFIGOstage(礦l=5434，x22=4328；P1=0066，P2=0118)，butoverexpressionofIGF一1correlatedwithcellulardifferentiation(f=7163，P=o028)(2)IGF1RaremembranereceptorsSevent

6、ypercentsspecimensofthecontrolgroupWerepositivestainingofIGF一1RwithoutoverexpressionPositiveexpressionofIGF一1RWasin6087％ofthecancerwithoverexpressionin3696％(moderatestainingin11casesandstrongstainingin17cases)Nosignifica

7、ntdifferenceofpositiveexpressionrateWasobservedbetweencancerandnormalgroups蜘511，P=O475)，butsignificantdifferenceofoverexpressionratesWasobtainedbetwveennormalandcancergroups研=8117，pq)004)Positiveexpressionandoverexpressi

8、onofIGF一1RwerenotassociatedwiththeFIGOstageZ21=5550，礦2：4369；P1=0062，P2=o111)butoverexpressionofIGF一1correlatewithcellulardifferentiationQ≮8584，P=0014)ConclusionsIGF1andIGF—lRarerelmedtopoordifferentiationoftheoancerTheym